Pregabalin in Neuropathic Pain: Evidences and Possible Mechanisms
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چکیده
منابع مشابه
Pregabalin in Neuropathic Pain: Evidences and Possible Mechanisms
Pregabalin is an antagonist of voltage gated Ca2+ channels and specifically binds to alpha-2-delta subunit to produce antiepileptic and analgesic actions. It successfully alleviates the symptoms of various types of neuropathic pain and presents itself as a first line therapeutic agent with remarkable safety and efficacy. Preclinical studies in various animal models of neuropathic pain have show...
متن کاملMorphine and pregabalin in the treatment of neuropathic pain
The drugs that are currently available to treat neuropathic pain exhibit inadequate efficacy and numerous adverse effects. The present study compared the efficacy of combination therapy with pregabalin and morphine with that of each as a single agent in patients with neuropathic pain. The primary measurement was mean daily pain intensity. Secondary measurements included a pain questionnaire, ad...
متن کاملMechanisms of neuropathic pain.
Neuropathic pain is de®ned as `pain initiated or caused by a primary lesion or dysfunction in the nervous system'. The spectrum of neuropathic pain covers a variety of disease states (Table 1) and presents in the clinic with a variety of symptoms. Neuropathic pain is often reported as having a lancinating or continuous burning character and is often associated with the appearance of abnormal se...
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Neuropathic pain is caused by functional abnormalities of structural lesions in the peripheral or central nervous system, and occurs without peripheral nociceptor stimulation. Many common diseases, such as postherpetic neuralgia, trigeminal neuralgia, diabetic neuropathy, spinal cord injury, cancer, stroke, and degenerative neurological diseases may produce neuropathic pain. Recently, theories ...
متن کاملMechanisms of Neuropathic Pain
Neuropathic pain refers to pain that originates from pathology of the nervous system. Diabetes, infection (herpes zoster), nerve compression, nerve trauma, "channelopathies," and autoimmune disease are examples of diseases that may cause neuropathic pain. The development of both animal models and newer pharmacological strategies has led to an explosion of interest in the underlying mechanisms. ...
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ژورنال
عنوان ژورنال: Current Neuropharmacology
سال: 2014
ISSN: 1570-159X
DOI: 10.2174/1570159x1201140117162802